Current Issue

2022: Volume 5, Issue 1

Chronic Inflammation and Its Role in Colorectal Cancer Development

Mohsen Mohammadi1, Jalil Mehrzad2*, Nourouz Delirezh1, Abbas Abdollahi3

1Department of Microbiology, Faculty of Veterinary Medicine, Urmia University, Iran

2Department of Microbiology and Immunology, Faculty of Veterinary Medicine, University of Tehran, Iran

3Department of Surgery, Faculty of Medicine, Mashhad University of Medical Sciences, Iran

*Corresponding author: Jalil Mehrzad, Professor of Immunology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran. Tel: 0021-61117053, Email: [email protected]

ABSTRACT

Colorectal cancer (CRC) is the third common cancer and fourth cancer related mortality, worldwide. Chronic Inflammation is one of the underlying mechanisms leads to this cancer. The final aim of this research was to assess the expression level of pattern recognition receptors (PRRs)-related genes TLR2, TLR4, NLRP3, NF-kβ, MBL1, GAL1 and oxidative agent NOS2 in colon tissue and blood monocytes of CRC patients to find the relative role of  chronic inflammation in the initiation of the CRC development. By this approach, the expression level of mentioned genes was assessed in colon tissues and monocytes of 24 cases (12 CRC and 12 healthy control persons) with 65±11 years old. In CRC patients’ monocytes, the expression level of TLR2, TLR4, GAL1 and MBL1 genes were significantly less than those of healthy controls (p<0.05). The expression level of NOS2 and NF-kβ genes in CRC patients’ monocytes was significantly higher than those of in healthy controls (p<0.05). In cancerous colon tissues, the expression level of TLR2, TLR4 and NLRP3 was significantly higher and in the case of NOS2 and NF-kβ the difference was not significant. But, the expression level of MBL1 was significantly lower than normal tissues (p<0.05) .In conclusion, since CRC development is normally accompanied by chronic inflammation, the observed significant differences at the expression level of some key inflammatory genes in monocytes and cancerous colon tissues of CRC patients, is highly related to chronic inflammatory reactions in tumor microenvironment.

Keywords: Toll like receptors 2, 4, NLR family pyrin domain containing 3 (NLRP3), Nitric oxide synthase2 (NOS2), Mannose binding lectin1 (MBL1), Galectin1 (GAL1), Nuclear factor kappa binding, beta actin (ACTB), Colorectal cancer (CRC)

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