2019: Volume 2, Issue 1
Past Issues
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PDFChromatographic Fractionation of An Ethanolic Extract of Peels from Ipomoea batatas Lam for Improved Anticancer Activity
Oluyori Abimbola P1*, Olatunji Gabriel A2, Shaw Arun K3, Rastogi Preeti3, Sanjeev Meena4, Dipak Datta4
1 Department of Physical Sciences, Landmark University, Omuaran, Kwara State, Nigeria
2 Department of Industrial Chemistry, University of Ilorin, Ilorin, Nigeria
3 Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow, India
4 Biochemistry Division, Central Drug Research Institute, Lucknow, India
Corresponding author: Oluyori Abimbola P, Department of Physical Sciences, Landmark University, Omuaran, Kwara State, Nigeria
Received: December 29, 2018
Published: January 15, 2019
Abstract
In this current work, the n-hexane fraction from an ethanolic extract of pulverized peel of Ipomoea batatas Lam was subjected to chromatographic fractionation. Consequently, the fractions were investigated for their anticancer potential using the Sulforhodamine-B assay. Chromatographic fractionation led to n-hexane sub-fractions with greater anticancer potential. The study highlights the peel of Ipomoea batatas Lam as a rich dietary source of natural anticancer molecules which may be developed into nutraceuticals or serve as new leads in anticancer therapy.
Keywords: Ipomoea batatas; Chromatography; Fractionation; Anticancer; Sulforhodamine-B
