Past Issues

2019: Volume 2, Issue 1

Chromatographic Fractionation of An Ethanolic Extract of Peels from Ipomoea batatas Lam for Improved Anticancer Activity

Oluyori Abimbola P1*, Olatunji Gabriel A2, Shaw Arun K3, Rastogi Preeti3, Sanjeev Meena4, Dipak Datta4

1 Department of Physical Sciences, Landmark University, Omuaran, Kwara State, Nigeria
2 Department of Industrial Chemistry, University of Ilorin, Ilorin, Nigeria
3 Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow, India
4 Biochemistry Division, Central Drug Research Institute, Lucknow, India

Corresponding author: Oluyori Abimbola P, Department of Physical Sciences, Landmark University, Omuaran, Kwara State, Nigeria

Received: December 29, 2018
Published: January 15, 2019

Abstract

In this current work, the n-hexane fraction from an ethanolic extract of pulverized peel of Ipomoea batatas Lam was subjected to chromatographic fractionation. Consequently, the fractions were investigated for their anticancer potential using the Sulforhodamine-B assay. Chromatographic fractionation led to n-hexane sub-fractions with greater anticancer potential. The study highlights the peel of Ipomoea batatas Lam as a rich dietary source of natural anticancer molecules which may be developed into nutraceuticals or serve as new leads in anticancer therapy.

KeywordsIpomoea batatas; Chromatography; Fractionation; Anticancer; Sulforhodamine-B

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